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Click on any filter to expand it and set it.

Filters, even if unselected, tell you just how your search results are distributed across various aspects of an interaction. The number of interactions that match a particular filter item with respect to the current query are displayed in parenthesis beside each item. As you refine your search these numbers will change to reflect the other filters selected and/or your search terms.

An interaction can be 'multi-valued' with respect to a filter. For example an interaction can be supported by evidence from several source databases, so it contributes to the match count of each those databases.

• • Source Database

    bind 62514

    bind_translation 59818

    biogrid 277504

    corum 2607

    dip 89456

    hprd 40487

    innatedb 7000

    intact 156120

    matrixdb 201

    mint 85641

    mpact 13331

    mpiimex 473

    mpilit 745

    mppi 830

    ophid 47393

    Can match ANY of these Must match ALL of these Must match NONE of these
     

    seen by 1 DB 375209

    seen by 2 DBs 65437

    seen by 3 or more DBs 76883
  • Organism **

    single organism interaction 484248

    cross organism interaction 33281
     

    Saccharomyces cerevisiae S288c 225572

    Homo sapiens 144350

    Drosophila melanogaster 37045

    Mus musculus 17701

    Escherichia coli K-12 17251

    Schizosaccharomyces pombe 972h- 15691

    Campylobacter jejuni 12029

    Caenorhabditis elegans 12001

    Arabidopsis thaliana 9628

    Escherichia coli O157:H7 6588

    Can match ANY of these Must match ALL of these Must match NONE of these
  • Nature of Interaction

    unary 16948

    pairwise 482253

    multi-subunit 18328
     

    predicted 47393

    experimental 491033
     

    genetic 142355

    physical 386495
• • MI (MINT-Inspired) Score

    0 or more 269332

    0.1 or more 269148

    0.2 or more 218003

    0.3 or more 163172

    0.4 or more 127044

    0.5 or more 92755

    0.6 or more 78596

    0.7 or more 65476

    0.8 or more 52487

    0.9 or more 40891

    Can match ANY of these Must match ALL of these Must match NONE of these

    MI (MINT Inspired) scores are in the range [0,1], are limited to interactions where all its proteins are the same species, supported by valid PubMed IDs, not predicted or from OPHID, not a self-interaction, and are from one of the following organisms:

    • A. thaliana
    • B. taurus
    • C. elegans
    • D. melanogaster
    • H. sapiens

    • M. musculus
    • O. sativa
    • R. norvegicus
    • S. cerevisiae
    • S. pombe

    Any interaction that does not meet the above requirements has no score calculated and this is displayed as 'n/c'

    Go here to find out how the score is calculated.

  • MI (MINT-Inspired) Organism Percentile

    0 or more 269332

    10 or more 268054

    20 or more 249771

    30 or more 212916

    40 or more 206368

    50 or more 145600

    60 or more 122297

    70 or more 97803

    80 or more 71861

    90 or more 27396

    Can match ANY of these Must match ALL of these Must match NONE of these
• • Interaction Detection Method *

    3 hybrid method 203

    DNase I footprinting 1

    acetylase assay 6

    adenylate cyclase complementation 163

    affinity chromatography technology 142794

    affinity technology 149112

    anti bait coimmunoprecipitation 12251

    anti tag coimmunoprecipitation 23374

    antibody array 85

    array technology 4165

    atomic force microscopy 10

    atpase assay 5

    beta galactosidase complementation 29

    beta lactamase complementation 30

    bimolecular fluorescence complementation 260

    biochemical 159864

    bioluminescence resonance energy transfer 47

    biophysical 16662

    biosensor 767

    blue native page 366

    chromatin immunoprecipitation assay 12

    chromatography technology 143280

    circular dichroism 37

    classical fluorescence spectroscopy 85

    cleavage assay 348

    coimmunoprecipitation 41556

    comigration in gel electrophoresis 676

    comigration in non denaturing gel electrophoresis 516

    comigration in sds page 20

    competition binding 547

    confirmational text mining 7342

    confocal microscopy 587

    cosedimentation 575

    cosedimentation in solution 129

    cosedimentation through density gradient 301

    cross-linking study 607

    cytoplasmic complementation assay 10682

    deacetylase assay 9

    demethylase assay 6

    detection by mass spectrometry 43

    dihydrofolate reductase reconstruction 9634

    display technology 1449

    dynamic light scattering 20

    electron microscopy 143

    electron paramagnetic resonance 3

    electron resonance 7

    electron tomography 3

    electrophoretic mobility shift assay 125

    electrophoretic mobility supershift assay 9

    electrophoretic mobility-based method 676

    enzymatic footprinting 4

    enzymatic study 9744

    enzyme linked immunosorbent assay 308

    experimental interaction detection 454393

    experimental knowledge based 11792

    far western blotting 1179

    filamentous phage display 13

    filter binding 282

    fluorescence correlation spectroscopy 9

    fluorescence microscopy 1252

    fluorescence polarization spectroscopy 142

    fluorescence technology 1306

    fluorescence-activated cell sorting 54

    fluorescent resonance energy transfer 607

    footprinting 24

    gal4 vp16 complementation 12

    genetic interference 142501

    green fluorescence protein complementation assay 10

    gtpase assay 1

    homogeneous time resolved fluorescence 5

    imaging technique 3807

    immunodepleted coimmunoprecipitation 12

    in-gel kinase assay 401

    inference 1603

    inferred by author 1115

    inferred by curator 494

    interaction detection method 517529

    interaction prediction 12073

    interologs mapping 8861

    ion exchange chromatography 35

    isothermal titration calorimetry 237

    kinase homogeneous time resolved fluorescence 3

    kinase scintillation proximity assay 2

    lambda phage display 11

    lambda repressor two hybrid 2

    lex-a dimerization assay 20

    light microscopy 7

    light scattering 64

    luminescence based mammalian interactome mapping 31

    mammalian protein protein interaction trap 23

    mass spectrometry studies of complexes 43

    membrane bound complementation assay 29

    methyltransferase assay 27

    methyltransferase radiometric assay 5

    molecular sieving 715

    nuclear magnetic resonance 262

    nuclease assay 1

    nucleic acid uv cross-linking assay 1

    nucleoside triphosphatase assay 6

    one hybrid 1

    peptide array 1904

    phage display 509

    phosphatase assay 285

    phosphotransferase assay 1276

    polymerization 3

    protease accessibility laddering 2

    protease assay 348

    protein array 1814

    protein complementation assay 142836

    protein cross-linking with a bifunctional reagent 56

    protein kinase assay 1272

    protein tri hybrid 177

    proteinchip(r) on a surface-enhanced laser desorption/ionization 1

    pull down 26901

    reverse phase chromatography 3

    reverse ras recruitment system 1

    reverse two hybrid 4

    ribonuclease assay 1

    saturation binding 50

    scintillation proximity assay 7

    sequence based prediction 8861

    solid phase assay 2067

    static light scattering 2

    structure based prediction 5

    surface plasmon resonance 767

    surface plasmon resonance array 144

    t7 phage display 3

    tandem affinity purification 34235

    text mining 7342

    tox-r dimerization assay 2

    transcriptional complementation assay 130250

    transmission electron microscopy 3

    two hybrid 130225

    two hybrid array 25857

    two hybrid fragment pooling approach 8798

    two hybrid pooling approach 51541

    ubiquitin reconstruction 880

    unspecified method 173520

    x ray scattering 12

    x-ray crystallography 13864

    yeast display 2

    zymography 1

    Can match ANY of these Must match ALL of these Must match NONE of these
  • Interaction Type *

    acetylation reaction 28

    additive genetic interaction defined by inequality 91719

    adp ribosylation reaction 4

    amidation reaction 1

    association 297428

    cleavage reaction 71

    colocalization 4786

    covalent binding 217

    deacetylation reaction 10

    demethylation reaction 6

    deneddylation reaction 1

    dephosphorylation reaction 260

    deubiquitination reaction 10

    direct interaction 89245

    disulfide bond 34

    dna strand elongation 1

    enzymatic reaction 1412

    epistatic genetic interaction 32136

    genetic interaction 142355

    genetic interaction defined by inequality 142355

    glycosylation reaction 2

    gtpase reaction 2

    hydroxylation reaction 3

    interaction type 434652

    lipid addition 6

    methylation reaction 45

    neddylation reaction 4

    negative genetic interaction 28319

    nucleic acid cleavage 1

    nucleic acid strand elongation reaction 1

    nucleoside triphosphatase reaction 2

    oxidoreductase activity electron transfer reaction 10

    palmitoylation reaction 6

    phosphorylation reaction 813

    phosphotransfer reaction 2

    physical association 263999

    positive genetic interaction 32136

    protein cleavage 35

    rna cleavage 1

    sumoylation reaction 12

    suppressive genetic interaction defined by inequality 32136

    synthetic genetic interaction defined by inequality 28319

    ubiquitination reaction 66

    unknown 118776

    Can match ANY of these Must match ALL of these Must match NONE of these
• • Number of Publications

    no valid PubMed ID 2926

    1 or more publications 514603

    2 or more publications 94677

    3 or more publications 27102

    4 or more publications 13680

    Can match ANY of these Must match ALL of these Must match NONE of these
  * Filter counts for interaction method and type propagate to their parent terms as defined by the PSI-MI ontology.
  Thus a selected method or type filter will return all of its child terms as well.
  ** Organism filter counts (for instance yeast and its subspecies) do not propagate.

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