Beta-Arrestin 2, isoform 1. Major regulators of GPCR signaling by binding to the activated GPCR and causing receptor desensitization and internalization; also involved in linking GPCRs to clathrin-coated pits, regulation of cytoskeletal rearrangement and cellular localization, translocation, or stability regulation of signaling elements.
| Interaction ID | Total Unique Proteins in Interaction | MI Score |
|---|---|---|
| 621894 | 3 | 0.43 |
| 627517 | 3 | 0.64 |
| 632217 | 4 | 0.98 |
| 656295 | 3 | 0.73 |
| 662413 | 3 | 0.80 |
| 1210585 | 3 | 0.86 |
| 681761 | 3 | n/c |
| 694764 | 3 | 0.92 |
| 702686 | 3 | 0.74 |
| 768284 | 3 | 0.28 |
| 823410 | 3 | 0.64 |
| 893448 | 3 | 0.98 |
| 909118 | 5 | 0.28 |
| 937930 | 3 | 0.82 |
| 989670 | 3 | 0.82 |
| 1003505 | 3 | 0.55 |
| 1054946 | 3 | n/c |
| 1074503 | 4 | 0.82 |
| 1117535 | 5 | 0.78 |
| Interaction ID | # of Protein Repeats | MI Score |
|---|
| Name Space | Alias |
|---|---|
| ensembl | ENSG00000141480 |
| entrezgene | 409 |
| gb | AAC99468.1 |
| gb | AAH07427.1 |
| gb | AAH67368.1 |
| gb | ABC40725.1 |
| gb | EAW90421.1 |
| gb | EAW90422.1 |
| gi | 4757780 |
| grid | 106902 |
| hgnc | 712 |
| hprd | {1} |
| interpro | IPR000698 |
| interpro | IPR011021 |
| interpro | IPR011022 |
| interpro | IPR014752 |
| interpro | IPR014753 |
| interpro | IPR014756 |
| interpro | IPR017864 |
| omim | 107941 |
| refseq | 409 |
| refseq | NP_004304 |
| refseq | NP_004304.1 |
| refseq | NP_945355 |
| refseq | NP_945355.1 |
| uniprot | B5B0C0 |
| uniprot | B7WPL3 |
| uniprot | D3DTK2 |
| uniprot | P32121 |
| uniprot | Q0Z8D3 |
| uniprot | Q2PP19 |
| uniprot | Q6ICT3 |
| uniprot | Q8N7Y2 |
| uniprot | Q9UEQ6 |