smg-2 - Caenorhabditis elegans (Gene:171696) - DAnCER - Wodak Lab

Description

Suppressor with Morphological effect on Genitalia

Species

Caenorhabditis elegans

Chromosome

I

CM Evidence

CM Status: Putative

Enzymatic Function

GO Annotations

GO biological process and molecular function terms related to CM are highlighted in red.

Molecular function

GO:0000166: nucleotide binding (IEA)
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
Annotated on O76512 with IEA (UniProtKB-KW:KW-0547)
GO:0003677: DNA binding (IEA)
Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
Annotated on O76512 with IEA (InterPro:IPR018999)
GO:0003723: RNA binding (IEA)
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Annotated on O76512 with IEA (UniProtKB-KW:KW-0694)
GO:0004386: helicase activity (IEA)
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
Annotated on O76512 with IEA (UniProtKB-KW:KW-0347)
GO:0005515: protein binding (IPI)
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
Annotated on O76512 with IPI (WB:WBGene00004883)
GO:0005524: ATP binding (IEA)
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Annotated on O76512 with IEA (UniProtKB-KW:KW-0067)
GO:0008270: zinc ion binding (IEA)
Interacting selectively and non-covalently with zinc (Zn) ions.
Annotated on O76512 with IEA (InterPro:IPR018999)
GO:0016787: hydrolase activity (IEA)
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
Annotated on O76512 with IEA (UniProtKB-KW:KW-0378)
GO:0017111: nucleoside-triphosphatase activity (IEA)
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
Annotated on O76512 with IEA (InterPro:IPR003593)
GO:0046872: metal ion binding (IEA)
Interacting selectively and non-covalently with any metal ion.
Annotated on O76512 with IEA (UniProtKB-KW:KW-0479)
GO:0051721: protein phosphatase 2A binding (IPI)
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
Annotated on O76512 with IPI (WB:WBGene00003901)

Biological process

GO:0000184: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IGI)
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Annotated on O76512 with IGI
GO:0016246: RNA interference (IMP)
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
Annotated on O76512 with IMP (WB:WBRNAi00069209)
GO:0030538: embryonic genitalia morphogenesis (IMP)
The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized.
Annotated on O76512 with IMP
GO:0040035: hermaphrodite genitalia development (IMP)
The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures.
Annotated on O76512 with IMP (WB:WBRNAi00075330)

Cellular component

GO:0005634: nucleus (IDA)
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Annotated on O76512 with IDA
GO:0005737: cytoplasm (IDA)
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Annotated on O76512 with IDA

CORUM Complexes

Not a member of any complex.

Interactions

Interacting Proteinsmg-2's ProteinSupporting PublicationsInteraction
CSN5_CAEEL (P91001) RENT1_CAEEL 1 iRef:1220864

Domains

Domains
Float your mouse over the coloured bars to see the domain name and sequence position. PFAM A is above the black line, PFAM B below.
DAnCER 2.3
Disease Annotated Chromatin Epigenetics Resource